Amyloid-beta Analysis and Characterization using Gel Electrophoresis
Brian Pham, Arizona State University, Undergraduate Student
This study pertains to the analysis and characterization of different species within samples of amyloid-beta 40 and amyloid-beta 42. The amyloid-beta precursor protein is secreted by cells and normally plays a vital role in the functioning of the nervous system. However, when these proteins aggregate into larger oligomers, they form neurotoxic deposits in the brain. This has been correlated with the pathogenesis of Alzheimer's disease. Characterizing amyloid-beta, however, proves demanding due to the heterogeneity of the aggregation states and its tendency to rapidly differentiate with time. Regardless, dedicating time to study the various amyloid-beta oligomeric states is critical and valuable to advancing knowledge on Alzheimer's disease.