Optical imaging techniques have been shown to be highly sensitive to early stages of cancer. Barton’s team has examined techniques, including optical coherence tomography, fluorescence imaging and multiphoton imaging, in mouse models of ovarian cancer and human samples of fallopian tube and ovary. These studies suggest that ovarian cancer is detectable at microscopic and macroscopic scales. To implement early detection in vivo, a minimally invasive method to reach the ovaries and fallopian tubes must be created. The Barton lab is developing endoscopes that travel a variety of paths through the female reproductive system and incorporate one or more of the optical modalities.