The Vision of Precision Medicine Takes Another Leap Forward

To enable a new era of medicine through research, technology, and policies that empower patients, researchers, and providers to work together toward development of individualized care. (Mission Statement of the White House Precision Medicine Initiative.)

On February 25, the White House hosted the Precision Medicine Initiative Summit marking the one-year anniversary of President Obama’s Precision Medicine Initiative (PMI) .



White House Precision Medicine Initiative Summit (Source:  The White House)

Click here to watch the full summit.  President Obama’s comments can be found at the 1:49:40 minute mark.

Click here to read the PMI Fact Sheet


Dr. Robert Califf, M.D. – Precision FDA

PrecisionFDA provides a private area where participants (individuals or organizations) can conduct genome analysis and comparison against reference material, and a community area where they can publish and share results, reference materials, and tools. The precisionFDA community continues to grow and includes:

  • Genome Test or Software Providers
  • Standards-making Bodies
  • Pharmaceutical & Biotechnology Companies
  • Healthcare Providers
  • Academic Medical Centers
  • Researchers
  • Patients
  • FDA & Other Government Agencies

Click here to see the list of precisionFDA Community Participants

Dr.Francis Collins: Precision Focused Health

“The Vision of Precision Medicine Takes another Leap Forward”- Dr. Francis Collins

  • Participants (people sharing their data) in the PMI will be partners in the Precision Medicine Initiative Cohort.
  • The PMI Cohort will represent America’s unique diversity
  • Data sharing across research partners will be swift

Dr. Collins announced Four Key First Steps

  1. awarding the Direct Volunteers Pilot Studies Program to Vanderbilt University, Nashville, Tennessee, in collaboration with advisors from Verily (formerly Google Life Sciences), Mountain View, California, to explore the optimal approaches and systems for engaging, enrolling, and retaining participants from across the United States in the PMI Cohort Program.
  2. collaborating with the Health Resources and Services Administration (HRSA) to begin partnerships with several Federally Qualified Health Centers to develop, pilot, and refine approaches for bringing underserved individuals, families, and communities into the PMI Cohort Program
  3. working with the HHS Office of the National Coordinator for Health IT (ONC) on a program called “Sync for Science,” which will pilot use of open, standardized applications to give individuals the ability to contribute their data to research, including for the PMI cohort when it is launched.
  4. establishing a central PMI Cohort Program Institutional Review Board (IRB)—with expertise in mHealth, bioinformatics, health disparities, epidemiology, genomics, and environmental health—for oversight and review of the research conducted in the Program. NIH has been at the forefront in creating central IRBs to ensure consistent, thoughtful, and timely review of human research participant issues.

Click here to read the complete post by Dr.Francis Collins


Precision Medicine Initiative: Privacy and Trust Principles

The principles provide broad guidance for future PMI activities regarding: governance; transparency; participant empowerment; respect for participant preferences; data sharing, access, and use; and data quality and integrity. The principles articulate a set of core values and responsible strategies for sustaining public trust and maximizing the benefits of precision medicine.

The principles include:

  • Creating a dynamic and inclusive governance structure
  • Building trust and accountability through transparency
  • Respecting participant preferences
  • Empowering participants through access to information.
  • Ensuring responsible data sharing, access, and use
  • Maintaining data quality and integrity

Click here to view the PMI Privacy and Trust Principles

Closer to Home: The University of Arizona’s Role in the PMI

The University of Arizona Health Sciences (UAHS) is announced  its participation in the national Precision Medicine Initiative®, as released earlier today by the White House.


In response to the national PMI, UAHS has committed significant resources to expand the clinical utility of its open-source, patient-centric analytic methods, such as the N-of-1-pathways software, which aids physicians in interpreting the dynamic changes of disease-associated gene expression arising from patients’ own DNA blueprints. As part of the initiative, UAHS will translate large-scale clinical and genomic data into actionable individual outcomes through two of its centers: the UA Center for Biomedical Informatics and Biostatistics (CB2) and the UA Center for Applied Genetics and Genomic Medicine (TCAG2M).

Both centers bring together physicians, scientists, patients and other key stakeholders to develop strategies that advance understanding of the factors contributing to individual health and disease and personalized approaches to disease prevention, early detection and treatment.

Looking at How it Began:  The Promise of Precision Medicine


Posted in AZBio News.