Dubois and Hartwell Named as Inaugural Fellows of the AACR

ASU Scientists Named as Inaugural Fellows of the American Association for Cancer Research

Arizona State University’s Nobel laureate Leland Hartwell, Ph.D., and physician-scientist Dr. Raymond DuBois, M.D., Ph.D., are among an elite group of scientists to be selected into the first class of Fellows of the American Association for Cancer Research.

“Our Board of Directors made the decision to establish the AACR Academy as a mechanism for recognizing scientists whose contributions to the cancer field have had an extraordinary impact. Membership in the Fellows of the AACR Academy will be the most prestigious honor bestowed by the American Association for Cancer Research,” said Margaret Foti, Ph.D., M.D. (h.c.), chief executive officer of the AACR.

The Fellows of the AACR Academy is a separate entity within the American Association for Cancer Research, and only individuals who have made exceptional contributions to cancer and/or cancer-related biomedical science are eligible for election. The inaugural class of Fellows of the AACR Academy consists of 106 individuals, symbolizing the age of the AACR upon establishment of the Academy.

ASU was among just a select handful of universities and worldwide institutions to have more than one scientist recognized and selected as an AACR Fellow.

“Drs. Hartwell and DuBois have made indelible contributions to changing our worldview of cancer research and the development of new paradigms and the way we think about the progression, treatment, and ultimately, prevention of cancer,” said ASU President Michael Crow. “We are tremendously proud of their accomplishments and recognition amongst peers as inaugural AACR Fellows. Hartwell and DuBois are key visionaries in carrying out ASU’s expanding research enterprise, and through their contributions and commitment to cancer research, science education, and the establishment of new partnerships, they are transforming the future of health care and translational medicine.”

Leland “Lee” Hartwell received the Nobel Prize in Medicine or Physiology for his pioneering work on genes that control cell growth and division, and their links to cancer. In 2009, he was recruited to ASU as the Virginia G. Piper Chair of Personalized Medicine, and chief scientist, Center for Sustainable Health at ASU’s Biodesign Institute, with a mission to sustain health through the integration of molecular and behavioral metrics, to improve health outcomes while reducing its costs, and advancing science education. At the Center, he continues his focus on molecular diagnostics and the establishment of a Global Biosignatures Network.

“I am very pleased to be included in the inaugural group of AACR Fellows,” said Hartwell.”  “This is an appropriate moment to initiate the AACR Academy since the basic science that they have so arduously supported over the years is beginning to impact disease management.”

From 1997-2009, Hartwell served as President and Director of the Fred Hutchinson Cancer Research Center, focusing the integration of basic, applied and clinical efforts of interdisciplinary cancer research. In 1998, he won the Albert Lasker Basic Medical Research Award for his innovative and pioneering work.

Raymond “Ray” DuBois is an internationally renowned expert who has explored the links between inflammation and cancer, particularly, the molecular and genetic basis of colon cancer and development of therapeutics to help in the prevention of colorectal cancer. In December of 2012, DuBois was named the executive director of ASU’s Biodesign Institute and holds joint appointments as the Dalton Chair, School of Health Solutions and professor in the Department of Chemistry and Biochemistry. In addition to his ASU responsibilities, his appointment includes co-leadership of the Cancer Prevention Program at the Mayo Clinic, where he plays a key role in realizing the potential of accelerating an active partnership between ASU and the Mayo Clinic.

“To be elected into the inaugural class of Fellows of the AACR Academy is quite a surprise and an incredible honor,” said DuBois.  “For over 100 years, the AACR has supported cancer researchers and helped advance the early detection, treatment and prevention of this disease. Current estimates indicate that over 50 percent of cancers are preventable. Ultimately, personalizing prevention strategies based on an individual’s risk and benefit will move the field forward rapidly. A combination of approaches involving diet, exercise, behavior modification and drug intervention will be most the most effective way to achieve success.”

The DuBois research team was the first to show that colorectal cancers over-expressed a pro-inflammatory enzyme called cyclooxygenase-2 (COX-2), and that blocking or inhibiting COX-2 would cause colorectal tumors to shrink. Both COX-1 and -2 are key enzymes for the production of prostaglandins.  This work led to additional research demonstrating crucial molecular links between prostaglandin (PGE2) signaling and progression of colorectal cancer. Blocking these pathways could have a significant impact on the prevention of colorectal cancer.

Prior to coming to ASU, DuBois was provost and executive vice president and professor of cancer medicine and cancer biology at the University of Texas MD Anderson Cancer Center in Houston.  At MD Anderson, he was responsible for developing and overseeing research strategy, faculty, the School of Health Professions, graduate education programs and initiatives, and Global Academic Programs.

DuBois is a Fellow of the American Association for the Advancement of Science, and past president of the American Association for Cancer Research. In addition, he is a founding scientific advisor for both the National Colon Cancer Research Alliance and Stand Up to Cancer.

The inaugural class of Fellows will be inducted into the AACR Academy on Friday, April 5, at the National Museum of Women in the Arts in Washington, D.C., as part of the AACR’s Annual Meeting April 6-10.

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