The Translational Genomics Research Institute (TGen) has received a $175,000 grant from the Hearst Foundation to study how to prevent cancer patients from dying due to lost weight and muscle mass.
Known as cachexia, or wasting syndrome, this condition is characterized not only by a loss of weight, but also by muscle atrophy, fatigue, weakness, and significant loss of appetite.
Cachexia (pronounced: kuh-kek’-see-uh) is responsible for more than 30 percent of deaths from cancer.
“What can we do to reverse the cachexia seen in cancer patients?” asks Dr. Daniel Von Hoff, TGen Distinguished Professor and Physician-In-Chief, who is considered one of the world’s leading authorities on development of new ways to treat cancer, and pancreatic cancer in particular, and the principal investigator of the study.
Dr. Von Hoff — who also is a Senior Consultant-Clinical Investigations for City of Hope, Chief Scientific Officer for the HonorHealth Research Institute and Professor of Medicine at Mayo Clinic — proposes that cachexia is associated with a cancer-caused conversion of white fat (stored fat) into brown fat (energy-burning fat).
“If we can stop the conversion of the white fat into brown fat, we should be able to reverse cachexia, and stop the weight loss, muscle weakness, anemia and loss of appetite, and hopefully help people feel more like living,” said Dr. Von Hoff, who currently leads an international Stand Up To Cancer (SU2C) Pancreatic Cancer Dream Team, developing new treatments for this disease.
More than 80 percent of patients with pancreatic cancer develop cachexia.
“Cachexia eventually leads to a situation in which the patients just don’t want to live anymore,” said Dr. Haiyong Han, Associate Professor of TGen’s Clinical Translational Research Division, and the co-investigator of the Hearst-funded study. “If we find a basic way to control cachexia, we have the ability to get it into a clinical trial and immediately begin to help patients.”
The TGen study proposes three potential methods of reversing cachexia, involving: febuxostat, an agent used to lower uric acid in patients with gout; nonselective beta-blockers, such as propranolol, used to treat high blood pressure; and the innovative transplantation of fat-related bacteria from the gut microbiome. If initial laboratory tests are positive for any of these investigations, the TGen team will move swiftly to recruit as many as 70 patients into clinical trials.
Dr. Von Hoff’s team at TGen and their collaborators have initiated three regimens of treatments in recent years that have improved the survival of patients with advanced pancreatic cancer. Most recently, these advances in therapies have resulted in improved 1, 2, 3 and 4-plus-year survival for patients with advanced late-stage pancreatic cancer.
Translational Genomics Research Institute (TGen) is a Phoenix, Arizona-based non-profit organization dedicated to conducting groundbreaking research with life changing results. TGen is focused on helping patients with neurological disorders, cancer, and diabetes, through cutting edge translational research (the process of rapidly moving research towards patient benefit). TGen physicians and scientists work to unravel the genetic components of both common and rare complex diseases in adults and children. Working with collaborators in the scientific and medical communities literally worldwide, TGen makes a substantial contribution to help our patients through efficiency and effectiveness of the translational process. TGen is allied with City of Hope, a world-renowned independent research and cancer and diabetes treatment center. This precision medicine alliance enables both institutes to complement each other in research and patient care, with City of Hope providing a significant clinical setting to advance scientific discoveries made by TGen. For more information, visit: http://www.
TGen Senior Science Writer
About the Hearst Foundations
The Hearst Foundations support nonprofit organizations working in culture, education, health, and social service in the United States. The charitable goals of the foundations reflect the philanthropic interests of William Randolph Hearst, with a focus on ensuring that people of all backgrounds have the opportunity to build healthy, productive, and inspiring lives. Please visit the foundations’ website http://www.