UACC Study looks at Broccoli and Tamoxifen – Participants Needed


A compound found in broccoli might be able to enhance the health-promoting effects of the breast cancer drug, Tamoxifen.


Researchers at The University of Arizona Cancer Center are continuing to seek participants for a study designed to determine if a compound found in broccoli can enhance the health-promoting effects of the breast cancer drug Tamoxifen in women at risk of developing breast cancer or those previously treated for early-stage breast cancer.

Since receiving a $3 million grant from the National Cancer Institute in 2011, UACC researcher Cynthia Thomson and her team have recruited about 50 women who are taking Tamoxifen for the DIME study. Enrollment will continue through December with a goal of 170 participants. Tamoxifen is an accepted treatment for breast cancer. Thomson, a professor of health promotion sciences in the Mel and Enid Zuckerman College of Public Health at the UA, notes that data from diet studies of people who have a higher intake of cruciferous vegetables – cauliflower, Brussels sprouts, kohlrabi and broccoli – suggest that intake may reduce the risk of certain cancers, including breast, colorectal, bladder and possibly prostate.

“We have previously shown that women taking Tamoxifen who eat more vegetables may decrease cancer recurrence risk. This study will test the potential health-promoting effects using one isolated bioactive compound found in cruciferous vegetables, diindolylmethane, and compare it to a placebo intervention in favorably changing hormone levels and breast characteristics like breast density,” Thomson said. Dr. Alison Stopeck, a co-investigator in the study and the director of the Clinical Breast Cancer Program at the UA Cancer Center, sees this research as a unique opportunity to determine the potential of non-invasive imaging to be a reliable biomarker for breast cancer risk. Women in the study will complete periodic magnetic resonance imaging procedures for measuring breast characteristics. Study participants will be asked to take the supplement or placebo for 18 months and complete periodic clinical evaluation visits.

The supplement is a patented, absorption enhancing formulation of diindolylmethane known as BioResponse DIM® (also known under the tradenames Indolplex® or BR-Dim®) supplied by BioResponse, LLC, of  Boulder, Colo.

The DIME Study is supported by grant number CA149417 from the National Cancer Institute of the National Institutes of Health.

The University of Arizona Cancer Center is the only National Cancer Institute-designated Comprehensive Cancer Center headquartered in Arizona. With primary locations at the UA in Tucson and at St. Joseph’s Hospital and Medical Center in Phoenix, the cancer center has more than a dozen research and education offices in Phoenix and throughout the state and 300 physician and scientist members work together to prevent and cure cancer.

Posted in AZBio News.